Combined Antibacterial Effects of Goat Cathelicidins With Different Mechanisms of Action.

ABSTRACT: Being essential components of innate immune system, animal antimicrobial peptides (AMPs) also known as host-defense peptides came into sharp focus as possible alternatives to conventional antibiotics due to their high efficacy against a broad range of MDR pathogens and low rate of resistance development. Mammalian species can produce a set of co-localized AMPs with different structures and mechanisms of actions. Here we examined the combined antibacterial effects of cathelicidins, structurally diverse family of host-defense peptides found in vertebrate species. As a model we have used structurally distinct cathelicidins expressed in the leukocytes of goat Capra hircus. The recombinant analogs of natural peptides were obtained by heterologous expression in bacterial system and biolog

SUBMITTER: Panteleev PV 

PROVIDER: S-EPMC6284057 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature