Lamotrigine Therapy for Bipolar Depression: Analysis of Self-Reported Patient Data.

ABSTRACT:

Background

Depression in people with bipolar disorder is a major cause of long-term disability, possibly leading to early mortality and currently, limited safe and effective therapies exist. Although existing monotherapies such as quetiapine have limited proven efficacy and practical tolerability, treatment combinations may lead to improved outcomes. Lamotrigine is an anticonvulsant currently licensed for the prevention of depressive relapses in individuals with bipolar disorder. A double-blinded randomized placebo-controlled trial (comparative evaluation of Quetiapine-Lamotrigine [CEQUEL] study) was conducted to evaluate the efficacy of lamotrigine plus quetiapine versus quetiapine monotherapy in patients with bipolar type I or type II disorders.

Objective

Because the origi

SUBMITTER: Nzeyimana A 

PROVIDER: S-EPMC6284142 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature