Sec23a mediates miR-200c augmented oligometastatic to polymetastatic progression.

ABSTRACT:

Background

Cancer treatment is based on tumor staging. Curative intent is only applied to localized tumors. Recent studies show that oligometastatic patients who have limited number of metastases may benefit from metastasis-directed local treatments to achieve long-term survival. However, mechanisms underlying oligometastatic to polymetastatic progression remains elusive.

Methods

The effects of miR-200c and Sec23a on tumor metastasis were verified both in vitro and in vivo. The secretome changes were detected by mass spectrometry.

Findings

We established a pair of homologous lung-metastasis derived oligometastatic and polymetastatic cell lines from human melanoma cancer cell line M14. Using the two cell lines, we have identified Sec23a, a gene target of miR-200c, supp

SUBMITTER: Sun Z 

PROVIDER: S-EPMC6284370 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature