A Schizophrenia-Related Genetic-Brain-Cognition Pathway Revealed in a Large Chinese Population.

ABSTRACT:

Background

In the past decades, substantial effort has been made to explore the genetic influence on brain structural/functional abnormalities in schizophrenia, as well as cognitive impairments. In this work, we aimed to extend previous studies to explore the internal mediation pathway among genetic factor, brain features and cognitive scores in a large Chinese dataset.

Methods

Gray matter (GM) volume, fractional amplitude of low-frequency fluctuations (fALFF), and 4522 schizophrenia-susceptible single nucleotide polymorphisms (SNP) from 905 Chinese subjects were jointly analyzed, to investigate the multimodal association. Based on the identified imaging-genetic pattern, correlations with cognition and mediation analysis were then conducted to reveal the potential mediation

SUBMITTER: Luo N 

PROVIDER: S-EPMC6284414 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature