Neuregulin1 types mRNA level changes in autism spectrum disorder, and is associated with deficit in executive functions.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a pediatric heterogeneous psychiatric and neurodevelopmental disorder with social and communication deficits, language impairment and ritualistic or repetitive behaviors. ASD has significant genetic bases but candidate genes and molecular mechanisms of disorder are not clarified. Neuregulin1 (NRG1) gene, located in 8p12 is involved in development of central nervous system and was indicated as candidate gene in schizophrenia.

Methods

mRNA level of types I, II and III of NRG1 gene were studied in peripheral blood of 1540 ASD patients (IQ > 70) and 1490 control children by quantitative Real Time PCR. Also three domains of executive functions (working memory, response inhibition and vigilance) were examined in all subjects.

Finding

SUBMITTER: Abbasy S 

PROVIDER: S-EPMC6284419 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature