Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease.

ABSTRACT:

Background

Epidemiological, laboratory and clinical studies have established an association between elevated urate and high blood pressure (BP). However, the inference of causality remains controversial. A naturally occurring antioxidant, urate may also be neuroprotective, and urate-elevating treatment with its precursor inosine is currently under clinical development as a potential disease-modifying strategy for Parkinson's disease (PD).

Methods

Our study takes advantage of a recently completed phase II trial evaluating oral inosine in de novo non-disabling early PD with no major cardiovascular and nephrological conditions, and of three lines of genetically engineered mice: urate oxidase (UOx) global knockout (gKO), conditional KO (cKO), and transgenic (Tg) mice with marked

SUBMITTER: Chen X 

PROVIDER: S-EPMC6284456 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature