Impacts of Diet and Exercise on Maternal Gut Microbiota Are Transferred to Offspring.

ABSTRACT: Background: It is well established that maternal exercise during pregnancy improves metabolic outcomes associated with obesity in mothers and offspring, however, its effects on the gut microbiota of both mother and offspring, are unknown. Here, we investigated whether wheel running exercise prior to and during pregnancy and prolonged feeding of an obesogenic diet were associated with changes in the gut microbiomes of Sprague-Dawley rat dams and their offspring. Female rats were fed either chow or obesogenic diet, and half of each diet group were given access to a running wheel 10 days before mating until delivery, while others remained sedentary. 16S rRNA gene amplicon sequencing was used to assess gut microbial communities in dams and their male and female offspring around the time

SUBMITTER: Bhagavata Srinivasan SP 

PROVIDER: S-EPMC6284474 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature