Rescuing ocular development in an anophthalmic pig by blastocyst complementation.

ABSTRACT: Porcine-derived xenogeneic sources for transplantation are a promising alternative strategy for providing organs for treatment of end-stage organ failure in human patients because of the shortage of human donor organs. The recently developed blastocyst or pluripotent stem cell (PSC) complementation strategy opens a new route for regenerating allogenic organs in miniature pigs. Since the eye is a complicated organ with highly specialized constituent tissues derived from different primordial cell lineages, the development of an intact eye from allogenic cells is a challenging task. Here, combining somatic cell nuclear transfer technology (SCNT) and an anophthalmic pig model (MITF^L247S/L247S), allogenic retinal pigmented epithelium cells (RPEs) were retrieved from

SUBMITTER: Zhang H 

PROVIDER: S-EPMC6284517 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature