Microbial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV.

ABSTRACT:

Objective

Immune activation is associated with morbidity and mortality during human immunodeficiency virus (HIV) infection, despite receipt of antiretroviral therapy (ART). We investigated whether microbial translocation drives immune activation in HIV-infected Ugandan children.

Methods

Nineteen markers of immune activation and inflammation were measured over 96 weeks in HIV-infected Ugandan children in the CHAPAS-3 Trial and HIV-uninfected age-matched controls. Microbial translocation was assessed using molecular techniques, including next-generation sequencing.

Results

Of 249 children included, 142 were infected with HIV; of these, 120 were ART naive, with a median age of 2.8 years (interquartile range [IQR], 1.7-4.0 years) and a median baseline CD4+ T-cell percenta

SUBMITTER: Fitzgerald FC 

PROVIDER: S-EPMC6284549 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature