Diagnostic accuracy of fecal calprotectin for screening patients with colorectal cancer: A meta-analysis.

ABSTRACT:

Background/aims

Fecal calprotectin (FC) is reported to have a broad diagnostic accuracy for colorectal cancer (CRC). Therefore, we explored the diagnostic value of FC for CRC using meta-analytical techniques to substantiate the assertion.

Materials and methods

An electronic search of the MEDLINE and Embase databases was conducted to identify studies that assessed the diagnostic accuracy of FC for CRC. The sensitivities and specificities of the eligible studies were summarized using a bivariable random-effects model.

Results

In total, 20 studies were included in the final analysis. The pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of FC for CRC detection were 0.83 (95% confidence interval CI, 0.77-0.88), 0.61 (95% CI, 0.54-0.

SUBMITTER: Ye X 

PROVIDER: S-EPMC6284629 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature