Super-enhancers are transcriptionally more active and cell type-specific than stretch enhancers.

ABSTRACT: Super-enhancers and stretch enhancers represent classes of transcriptional enhancers that have been shown to control the expression of cell identity genes and carry disease- and trait-associated variants. Specifically, super-enhancers are clusters of enhancers defined based on the binding occupancy of master transcription factors, chromatin regulators, or chromatin marks, while stretch enhancers are large chromatin-defined regulatory regions of at least 3,000 base pairs. Several studies have characterized these regulatory regions in numerous cell types and tissues to decipher their functional importance. However, the differences and similarities between these regulatory regions have not been fully assessed. We integrated genomic, epigenomic, and transcriptomic data from ten human cell type

SUBMITTER: Khan A 

PROVIDER: S-EPMC6284781 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature