Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk.

ABSTRACT: High blood concentrations of C-reactive protein (CRP) have been associated with elevated risk of colorectal cancer in several prospective studies including the European Prospective Investigation into Cancer and Nutrition (EPIC), but it is unknown whether these observations reflect a causal relationship. We aimed to investigate whether CRP genetic variants associated with lifelong higher CRP concentrations translate into higher colorectal cancer risk. We conducted a prospective nested case-control study within EPIC including 727 cases diagnosed between 1992 and 2003 and 727 matched controls selected according to an incidence-density sampling protocol. Baseline CRP concentrations were measured in plasma samples by a high sensitivity assay. Tagging single nucleotide polymorphisms (SNPs) in th

SUBMITTER: Nimptsch K 

PROVIDER: S-EPMC6284796 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature