Limitations of current in vitro models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma.

ABSTRACT:

Background

Epigenetic modifications have been shown to play an important role in the classification and pathogenesis of the pediatric brain tumor ependymoma, suggesting they are a potential therapeutic target.

Results

Agents targeting epigenetic modifications inhibited the growth and induced the death of ependymoma cells with variable efficiency. However, this was often not at clinically achievable doses. Additionally, DNA methylation profiling revealed a lack of similarity to primary ependymomas suggesting alterations were induced during culture. Toxicity to fetal neural stem cells was also seen at similar drug concentrations.

Conclusions

Agents targeting epigenetic modifications were able to inhibit the growth and induced the death of ependymoma cells grown in vi

SUBMITTER: Rogers HA 

PROVIDER: S-EPMC6284855 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature