Intratumoral CD56^bright natural killer cells are associated with improved survival in bladder cancer.

ABSTRACT:

Background

Natural killer (NK) cells are effective at killing tumors in a non-MHC restricted manner and are emerging targets for cancer therapy but their importance in bladder cancer (BC) is poorly defined. NK cells are commonly subdivided into populations based on relative surface expression of CD56. Two major subsets are CD56^bright and CD56^dim NK cells.

Methods

The prevalence of intratumoral lymphocytes was examined via flow cytometric analysis of bladder tissue from a local cohort of patients with non-invasive and invasive BC (n=28). The association of NK cell subsets with cancer-specific survival (CSS) and overall survival (OS) was examined in 50 patients with BC using Cox regression. Fluorescence-activated cell sorting (FACS) of intratumoral lympho

SUBMITTER: Mukherjee N 

PROVIDER: S-EPMC6284861 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature