Thiazide-associated hyponatremia attenuates the fracture-protective effect of thiazide: A population-based study.

ABSTRACT:

Background

Thiazide, a first-line therapy for hypertension, lowers blood pressure, increases bone mineral density, and reduces the risk of fractures. However, hyponatremia, an adverse effect of thiazide, is associated with increased risk of osteoporosis and fractures. It is currently unclear whether thiazide-associated hyponatremia (TAH) outweighs the protective effects of thiazide.

Methods

Using data from Taiwan's National Health Insurance Research Database, we identified patients who were prescribed thiazide between 1998 and 2010. Those diagnosed with hyponatremia within three years after initiation of thiazide were selected for the TAH group. Thiazide users without hyponatremia were selected for the control group. The association between TAH and fracture risk was further

SUBMITTER: Yang LJ 

PROVIDER: S-EPMC6285977 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature