VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population.

ABSTRACT:

Background

Leprosy is a chronic infectious disease caused by Mycobacterium leprae and mainly affects skin, peripheral nerves. Vitamin D receptor (VDR) gene polymorphism has been found to be associated with leprosy. Vitamin D has been shown to control several host immunomodulating properties through VDR gene. Vitamin D deficiency was also found to be linked to an increased risk for several infections and metabolic diseases.

Objective

In the present study, we investigated the association of VDR gene polymorphism, mRNA gene expression of VDR and the vitamin D levels with leprosy and its reactional states.

Methodology

A total of 305 leprosy patients consisting of tuberculoid (TT), borderline tuberculoid (BT), borderline lepromatous (BL), lepromatous leprosy (LL), as well

SUBMITTER: Singh I 

PROVIDER: S-EPMC6286024 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature