Transcriptional profiling identifies novel regulators of macrophage polarization.

ABSTRACT: Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. Major advances have occurred in understanding the transcriptional, epigenetic, and functional differences in various macrophage subsets by in vitro modeling and gene expression and epigenetic profiling for biomarker discovery. However, there is still no standardized protocol for macrophage polarization largely due to the lack of thorough validation of macrophage phenotypes following polarization. In addition, transcriptional regulation is recognized as a major mechanism governing differential macrophage polarization programs and as such, many genes have been identified to be associated with each macrophage subset. However, the functional role of many of t

SUBMITTER: Gerrick KY 

PROVIDER: S-EPMC6286176 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature