Epigenetic signatures of starting and stopping smoking.

ABSTRACT:

Background

Multiple studies have made robust associations between differential DNA methylation and exposure to cigarette smoke. But whether a DNA methylation phenotype is established immediately upon exposure, or only after prolonged exposure is less well-established. Here, we assess DNA methylation patterns from peripheral blood samples in current smokers in response to dose and duration of exposure, along with the effects of smoking cessation on DNA methylation in former smokers.

Methods

Dimensionality reduction was applied to DNA methylation data at 90 previously identified smoking-associated CpG sites for over 4900 individuals in the Generation Scotland cohort. K-means clustering was performed to identify clusters associated with current and never smoker status based on

SUBMITTER: McCartney DL 

PROVIDER: S-EPMC6286188 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature