Circulating miRNAs as footprints for liver fibrosis grading in schistosomiasis.

ABSTRACT:

Background

Chronic infection with Schistosoma japonicum or S. mansoni results in hepatic fibrosis of the human host. Staging fibrosis is crucial for the prognosis and to determine the rapid need of treatment in patients with schistosomiasis.

Methods

To establish whether there is a correlation between circulating microRNA (miRNA) level and fibrosis progression in schistosomiasis, ten miRNAs were selected to assess their potential in grading schistosomiasis liver fibrosis. This was done firstly in two mouse strains (C57BL/6 and BALB/c) to determine the temporal expression profiles in serum over the course of S. japonicum infection, and then within a cohort of 163 schistosomiasis japonica patients with different grades of liver fibrosis.

Finding

Four miRNAs (miR-150-5p,

SUBMITTER: Cai P 

PROVIDER: S-EPMC6286190 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature