Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity.

ABSTRACT:

Background

Previous studies indicate that low initial sensitivity to alcohol may be a risk factor for later alcohol misuse. Evidence suggests that initial sensitivity is influenced by genetic factors, but few molecular genetic studies have been reported.

Methods

We conducted a meta-analysis of 2 population-based genome-wide association studies of the Self-Rating of the Effects of Alcohol scale. Our final sample consisted of 7,339 individuals (82.3% of European descent; 59.2% female) who reported having used alcohol at least 5 times. In addition, we estimated single nucleotide polymorphism (SNP)-based heritability and conducted a series of secondary aggregate genetic analyses.

Results

No individual locus reached genome-wide significance. Gene and set based analyses, bo

SUBMITTER: Edwards AC 

PROVIDER: S-EPMC6286211 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature