Mechanisms underlying prelimbic prefrontal cortex mGlu₃/mGlu₅-dependent plasticity and reversal learning deficits following acute stress.

ABSTRACT: Stress can precipitate or worsen symptoms of many psychiatric illnesses. Dysregulation of the prefrontal cortex (PFC) glutamate system may underlie these disruptions and restoring PFC glutamate signaling has emerged as a promising avenue for the treatment of stress disorders. Recently, we demonstrated that activation of metabotropic glutamate receptor subtype 3 (mGlu₃) induces a postsynaptic form of long-term depression (LTD) that is dependent on the activity of another subtype, mGlu₅. Stress exposure disrupted this plasticity, but the underlying signaling mechanisms and involvement in higher-order cognition have not yet been investigated. Acute stress was applied by 20-min restraint and early reversal learning was evaluated in an operant-based food-seeking task. We e

SUBMITTER: Joffe ME 

PROVIDER: S-EPMC6286225 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature