Calcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial.

ABSTRACT:

Objective

Serrated lesions such as sessile serrated adenomas or polyps (SSA/Ps) are important colorectal cancer precursors, but aetiological factors for these lesions are largely unknown. We aimed to determine the effects of calcium and vitamin D supplementation on the incidence of serrated polyps (SPs) in general and hyperplastic polyps and SSA/Ps specifically.

Design

Participants with one or more adenoma at baseline were randomised to receive 1200 mg/day of elemental calcium, 1000 IU/day of vitamin D₃, both or neither agent. Treatment continued for 3 or 5 years, when risk of polyps was determined from surveillance colonoscopy (treatment phase). Outcomes after treatment ceased were also assessed (observational phase). Adjusted risk ratios (aRRs) of SPs were deter

SUBMITTER: Crockett SD 

PROVIDER: S-EPMC6286251 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature