A renal-cerebral-peripheral sympathetic reflex mediates insulin resistance in chronic kidney disease.

ABSTRACT:

Background

Insulin resistance (IR) complicates chronic kidney disease (CKD). We tested the hypothesis that CKD activates a broad reflex response from the kidneys and the white adipose tissue to impair peripheral glucose uptake and investigated the role of salt intake in this process.

Methods

5/6-nephrectomized rats were administered normal- or high-salt for 3 weeks. Conclusions were tested in 100 non-diabetic patients with stage 3-5 CKD.

Findings

High-salt in 5/6-nephrectomized rats decreased insulin-stimulated 2-deoxyglucose uptake >25% via a sympathetic nervous system (SNS) reflex that linked the IR to reactive oxygen species (ROS) and the renin-angiotensin system (RAS) in brain and peripheral tissues. Salt-loading in CKD enhanced inflammation in adipose tissue and

SUBMITTER: Cao W 

PROVIDER: S-EPMC6286258 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature