Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults.

ABSTRACT: Impulsivity is a transdiagnostic feature of a range of externalizing psychiatric disorders. Preclinical work links reduced ventral striatal dopamine transporter (DAT) availability with heightened impulsivity and novelty seeking. However, there is a lack of human data investigating the relationship between DAT availability, particularly in subregions of the striatum, and the personality traits of impulsivity and novelty seeking. Here we collected PET measures of DAT availability (BP_ND) using the tracer ¹⁸F-FE-PE2I in 47 healthy adult subjects and examined relations between BP_ND in striatum, including its subregions: caudate, putamen, and ventral striatum (VS), and trait impulsivity (Barratt Impulsiveness Scale: BIS-11) and novelty seeking (Tridimensional Per

SUBMITTER: Smith CT 

PROVIDER: S-EPMC6286354 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature