Glucose-Mediated Glucose Disposal at Baseline Insulin Is Impaired in IFG.

ABSTRACT:

Objective

To quantify glucose-mediated glucose disposal with and without basal insulin replacement and insulin-mediated glucose disposal in subjects with impaired fasting glucose (IFG).

Research design and methods

We used the hyperglycemic/pancreatic clamp and stepped euglycemic clamp techniques to quantify glucose disposal and suppression of endogenous glucose production (EGP) in those with normal glucose tolerance (NGT; n = 14) and those with IFG (n = 14).

Results

Total body glucose-mediated glucose uptake, measured with the hyperglycemic/pancreatic clamp, was not significantly affected by the basal plasma insulin levels in subjects with IFG and those with NGT. Compared with subjects with NGT, those with IFG had significantly lower glucose-mediated glucose uptake (b

SUBMITTER: Alatrach M 

PROVIDER: S-EPMC6286408 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature