Incidence and Risk of Gallstone Disease in Gilbert's Syndrome Patients in Indian Population.

ABSTRACT:

Background/objectives

Individuals with Gilbert's syndrome (GS) harbor mutations in the UGT1A1 gene and are known to have elevated levels of bilirubin, which enhances the risk for gall stone formation. The aim of this study is to screen Indian patients with GS for the incidence of gall stone disease.

Methods

Individuals with persistently elevated serum bilirubin levels were genotyped for two polymorphisms (rs8175347; rs4148323) in UGT1A1 gene to confirm GS in them. Flanking regions of the above polymorphisms were amplified followed by direct sequencing. Ultrasonography was done to detect gallstone disease. Clinical data, including assessment of liver function, circulating levels of total and direct bilirubin, as well as routine hematological parameters were obta

SUBMITTER: Bale G 

PROVIDER: S-EPMC6286431 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature