Metabolomics for predicting fetal growth restriction: protocol for a systematic review and meta-analysis.

ABSTRACT:

Introduction

Fetal growth restriction (FGR) is a relevant research and clinical concern since it is related to higher risks of adverse outcomes at any period of life. Current predictive tools in pregnancy (clinical factors, ultrasound scan, placenta-related biomarkers) fail to identify the true growth-restricted fetus. However, technologies based on metabolomics have generated interesting findings and seem promising. In this systematic review, we will address diagnostic accuracy of metabolomics analyses in predicting FGR.

Methods and analysis

Our primary outcome is small for gestational age infant, as a surrogate for FGR, defined as birth weight below the 10th centile by customised or population-based curves for gestational age. A detailed systematic literature search will b

SUBMITTER: Leite DFB 

PROVIDER: S-EPMC6286473 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature