Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study.

ABSTRACT:

Background

Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying diseases and clinical interventions, potentially influencing patient outcomes. We sought to profile the microbial composition of critically ill mechanically ventilated patients, and to determine whether microbial diversity is associated with illness severity and mortality.

Methods

We conducted a prospective, observational study of mechanically ventilated critically ill patients with a high incidence of pneumonia in 2 intensive care units (ICUs) in Hamilton, Canada, nested within a randomized trial for the prevention of healthcare-associated infections. The mi

SUBMITTER: Lamarche D 

PROVIDER: S-EPMC6286574 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature