Gut microbiota and plasma metabolites associated with diabetes in women with, or at high risk for, HIV infection.

ABSTRACT:

Background

Gut microbiota alteration has been implicated in HIV infection and metabolic disorders. The relationship between gut microbiota and diabetes has rarely been studied in HIV-infected individuals, who have excess risk of metabolic disorders.

Methods

Our study during 2015-2016 enrolled predominantly African Americans and Hispanics in the Women's Interagency HIV Study. We studied 28 women with long-standing HIV infection under antiretroviral therapy and 20 HIV-uninfected, but at high risk of infection, women (16 HIV+ and 6 HIV- with diabetes). Fecal samples were analyzed by sequencing prokaryotic16S rRNA gene. Plasma metabolomics profiling was performed by liquid chromatography-tandem mass spectrometry.

Findings

No significant differences in bacterial α- or β-di

SUBMITTER: Moon JY 

PROVIDER: S-EPMC6286648 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature