The global burden of sickle cell disease in children under five years of age: a systematic review and meta-analysis.

ABSTRACT:

Background

Sickle cell disease (SCD) is a common haematological disorder, affecting millions of people worldwide. It is most prevalent in malarial endemic areas in the tropics where outcomes are often poor due to resource constraints, resulting in most children dying before reaching adulthood. As increasing progress is made towards reducing under 5 mortality from infectious causes, non-communicable diseases (NCDs) including SCD have risen to the forefront of the global health agenda. Despite this, the global mortality burden of SCD remains poorly understood. This study aimed to estimate the incidence and mortality of SCD in children under 5 years of age in order to inform policy and develop sustainable strategies to improve outcomes.

Methodology

We performed a systematic lit

SUBMITTER: Wastnedge E 

PROVIDER: S-EPMC6286674 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature