The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters.

ABSTRACT: The cause of endometriosis remains unknown. However, studies investigating the link between this condition and the immune system revealed several immunological abnormalities focused on cell-mediated immunity. As a major immune checkpoint, programmed cell death protein 1 (PD-1) displays an important inhibitory function in the maintenance of peripheral tolerance. The expression of PD-1 and its ligand (PD-L1) may contribute to continuous T cell activation and development of inflammation and injury of the tissue. To our knowledge, this is the first study evaluating frequencies of PD-1-positive T CD3⁺ cells (CD4⁺ and CD8⁺) and B cells (CD19⁺) in patients with endometriosis. Peripheral blood (PB) samples from 25 female patients and 20 healthy age and s

SUBMITTER: Walankiewicz M 

PROVIDER: S-EPMC6286737 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature