Development and internal validation of a nine-lncRNA prognostic signature for prediction of overall survival in colorectal cancer patients.

ABSTRACT:

Background

Colorectal cancer remains a serious public health problem due to the poor prognosis. In the present study, we attempted to develop and validate a prognostic signature to predict the individual mortality risk in colorectal cancer patients.

Materials and methods

The original study datasets were downloaded from The Cancer Genome Atlas database. The present study finally included 424 colorectal cancer patients with wholly gene expression information and overall survival information.

Results

A nine-lncRNA prognostic signature was built through univariate and multivariate Cox proportional regression model. Time-dependent receiver operating characteristic curves in model cohort demonstrated that the Harrell's concordance indexes of nine-lncRNA prognostic signature

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC6286799 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature