Cell and tissue type independent age-associated DNA methylation changes are not rare but common.

ABSTRACT: Age-associated DNA methylation changes have been widely reported across many different tissue and cell types. Epigenetic 'clocks' that can predict chronological age with a surprisingly high degree of accuracy appear to do so independently of tissue and cell-type, suggesting that a component of epigenetic drift is cell-type independent. However, the relative amount of age-associated DNAm changes that are specific to a cell or tissue type versus the amount that occurs independently of cell or tissue type is unclear and a matter of debate, with a recent study concluding that most epigenetic drift is tissue-specific. Here, we perform a novel comprehensive statistical analysis, including matched multi cell-type and multi-tissue DNA methylation profiles from the same individuals and adjusting fo

SUBMITTER: Zhu T 

PROVIDER: S-EPMC6286821 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature