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MiR-150-5p suppresses tumor progression by targeting VEGFA in colorectal cancer.

ABSTRACT: MicroRNA-150-5p (miR-150-5p) has been implicated in tumor initiation and progression in a variety of cancers. However, its roles in colorectal cancer (CRC) remain largely unknown. In our study, a decreased miR-150-5p expression in CRC tissues was found to be associated with poor overall survival. Moreover, miR-150-5p inhibited CRC cell proliferation, migration, invasion and angiogenesis in vitro and in vivo, and its inhibitory effect could be reversed by transfection of vascular epithelial growth factor A (VEGFA) expression plasmid. Lastly, we demonstrated that miR-150-5p inactivated VEGFA/VEGFR2 and the downstream Akt/mTOR signaling pathway in CRC. Based on these results, we conclude that miR-150-5p may function as a tumor suppressor in CRC, and miR-150-5p/VEGFA axis may be a potential therapeutic target candidate in CRC treatment.

SUBMITTER: Chen X 

PROVIDER: S-EPMC6286841 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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miR-150-5p suppresses tumor progression by targeting VEGFA in colorectal cancer.

Chen Xiaoxiang X   Xu Xueni X   Pan Bei B   Zeng Kaixuan K   Xu Mu M   Liu Xiangxiang X   He Bangshun B   Pan Yuqin Y   Sun Huiling H   Wang Shukui S  

Aging 20181101 11

MicroRNA-150-5p (miR-150-5p) has been implicated in tumor initiation and progression in a variety of cancers. However, its roles in colorectal cancer (CRC) remain largely unknown. In our study, a decreased miR-150-5p expression in CRC tissues was found to be associated with poor overall survival. Moreover, miR-150-5p inhibited CRC cell proliferation, migration, invasion and angiogenesis in vitro and in vivo, and its inhibitory effect could be reversed by transfection of vascular epithelial growt  ...[more]