Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms.

ABSTRACT:

Background

Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children.

Methods

A narrative review was performed searching studies on PubMed published in English language in 2004-2017, using appropriate key words, including "aging", "children", "HIV", "AIDS", "immunosenescence", "pathogenesis", "clinical conditions".

Results

Premature immunosenescence phenotype of B and T cells in HIV-infected children is mediated through immune system activation and chronic inflammation. Ongoing inflammation processes have been documented by increased levels of pathogen-associated molecular patterns (PAMPS), increased mitochondrial damage, higher levels of pro-inflammatory cy

SUBMITTER: Chiappini E 

PROVIDER: S-EPMC6286860 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature