Isolated Limb Perfusion With Melphalan Triggers Immune Activation in Melanoma Patients.

ABSTRACT: Hyperthermic isolated limb perfusion with melphalan (M-ILP) is a treatment option for melanoma patients with metastases confined to the limbs. This study aimed at defining the role of cellular immunity for the clinical response to M-ILP in melanoma patients. It was observed that patients with enhanced cytotoxic CD8⁺ T cell reactivity to common antigens (HCMV/EBV/influenza virus) prior to M-ILP were more likely to achieve a complete disappearance of macroscopic tumors (complete response). Following M-ILP treatment, the proportions of CD16⁺ intermediate and non-classical monocytes in peripheral blood were significantly enhanced along with induction of HLA-DR on CD4⁺ and CD8⁺ T cells. For further studies of the mechanism behind melphalan-induced imm

SUBMITTER: Johansson J 

PROVIDER: S-EPMC6286961 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature