Dataset Information
Association of MiR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease.
Ontology highlight
ABSTRACT: Background
Coronary artery disease (CAD) is the most common cause of mortality and disability from incommunicable disease in the world. Although the association between the single nucleotide polymorphisms (SNPs) in protein-coding genes and the risk of CAD has been investigated extensively, very few heart-disease associated studies concerning the SNPs in miRNA genes have been reported. The present study was performed to elucidate the association between the pre-microRNA-149 (miR-149) SNP rs2292832 and the risk of CAD in an Iranian population.Methods
Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to identify the genotypes of the miR-149 SNP rs2292832 in 421 unrelated subjects (272 with CAD and 149 controls).Results
Our analysis revealed that the TT genotype was more frequent in CAD patients than control subjects (P=0.02) implying that TT genotype should be considered as a risk factor in CAD development (TT vs. TC+CC p=0.02, OR=1.88).Conclusions
The present study suggests that rs2292832-TT in pre-miR-149 is associated with CAD in an Iranian population.
SUBMITTER: Ghaffarzadeh M
PROVIDER: S-EPMC6287219 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Association of MiR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease.
Journal of medical biochemistry 20170714 3
<h4>Background</h4>Coronary artery disease (CAD) is the most common cause of mortality and disability from incommunicable disease in the world. Although the association between the single nucleotide polymorphisms (SNPs) in protein-coding genes and the risk of CAD has been investigated extensively, very few heart-disease associated studies concerning the SNPs in miRNA genes have been reported. The present study was performed to elucidate the association between the pre-microRNA-149 (miR-149) SNP ...[more]
