Association of MiR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease.

ABSTRACT:

Background

Coronary artery disease (CAD) is the most common cause of mortality and disability from incommunicable disease in the world. Although the association between the single nucleotide polymorphisms (SNPs) in protein-coding genes and the risk of CAD has been investigated extensively, very few heart-disease associated studies concerning the SNPs in miRNA genes have been reported. The present study was performed to elucidate the association between the pre-microRNA-149 (miR-149) SNP rs2292832 and the risk of CAD in an Iranian population.

Methods

Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to identify the genotypes of the miR-149 SNP rs2292832 in 421 unrelated subjects (272 with CAD and 149 controls).

Results

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SUBMITTER: Ghaffarzadeh M 

PROVIDER: S-EPMC6287219 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature