Precocious subcutaneous abdominal stem cell development to adipocytes in normal-weight women with polycystic ovary syndrome.

ABSTRACT:

Objective

To examine whether abnormal subcutaneous (SC) abdominal adipose stem cell (ASC) development to adipocytes in polycystic ovary syndrome (PCOS) correlates with hyperandrogenism.

Design

Prospective cohort study.

Setting

Academic medical center.

Patient(s)

Eight normal-weight women with PCOS and eight normoandrogenic ovulatory (control) women matched for age and body mass index.

Intervention(s)

Circulating hormone and metabolic measurements, intravenous glucose tolerance testing, total body dual-energy X-ray absorptiometry, and SC abdominal fat biopsy.

Main outcome measure(s)

In vitro ASC commitment to preadipocytes (ZFP423 protein expression, day 0.5), preadipocyte differentiation to adipocytes (PPARγ gene expression, day 3) and adipocyte l

SUBMITTER: Fisch SC 

PROVIDER: S-EPMC6287278 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature