Unknown

Dataset Information

0

Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance.

ABSTRACT: BACKGROUND:Spreading Plasmodium falciparum artemisinin drug resistance threatens global malaria public health gains. Limited data exist to define the extent of P. falciparum artemisinin resistance southeast of the Greater Mekong region in Malaysia. METHODS:A clinical efficacy study of oral artesunate (total target dose 12 mg/kg) daily for 3 days was conducted in patients with uncomplicated falciparum malaria and a parasite count?

SUBMITTER: Grigg MJ 

PROVIDER: S-EPMC6287347 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance.

Grigg Matthew J MJ   William Timothy T   Piera Kim A KA   Rajahram Giri S GS   Jelip Jenarun J   Aziz Ammar A   Menon Jayaram J   Marfurt Jutta J   Price Ric N RN   Auburn Sarah S   Barber Bridget E BE   Yeo Tsin W TW   Anstey Nicholas M NM  

Malaria journal 20181210 1

<h4>Background</h4>Spreading Plasmodium falciparum artemisinin drug resistance threatens global malaria public health gains. Limited data exist to define the extent of P. falciparum artemisinin resistance southeast of the Greater Mekong region in Malaysia.<h4>Methods</h4>A clinical efficacy study of oral artesunate (total target dose 12 mg/kg) daily for 3 days was conducted in patients with uncomplicated falciparum malaria and a parasite count < 100,000/µL admitted to 3 adjacent district hospita  ...[more]

Similar Datasets

Unknown Surveillance of artemisinin resistance in Plasmodium falciparum in India using the kelch13 molecular marker.
| S-EPMC4394795 | biostudies-literature
Unknown Surveillance of molecular markers of Plasmodium falciparum artemisinin resistance (kelch13 mutations) in Papua New Guinea between 2016 and 2018.
| S-EPMC8286961 | biostudies-literature
Unknown A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.
| S-EPMC5007947 | biostudies-literature
Unknown Genetic Diversity of Plasmodium falciparum Populations in Malaria Declining Areas of Sabah, East Malaysia.
| S-EPMC4811561 | biostudies-literature
Unknown Limited Polymorphism in Plasmodium falciparum Artemisinin Resistance Kelch13-Propeller Gene Among Clinical Isolates from Bushenyi District, Uganda.
| S-EPMC8665267 | biostudies-literature
Unknown Artemisinin combination therapy fails even in the absence of Plasmodium falciparum kelch13 gene polymorphism in Central India.
| S-EPMC8113598 | biostudies-literature
Unknown Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.
| S-EPMC7541349 | biostudies-literature
Unknown Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum.
| S-EPMC8600086 | biostudies-literature
Unknown Full-length sequence analysis of chloroquine resistance transporter gene in Plasmodium falciparum isolates from Sabah, Malaysia.
| S-EPMC4276362 | biostudies-literature
Unknown Status of Artemisinin Resistance in Malaria Parasite Plasmodium falciparum from Molecular Analyses of the Kelch13 Gene in Southwestern Nigeria.
| S-EPMC6192135 | biostudies-literature