Liver Fat and Insulin Sensitivity Define Metabolite Profiles During a Glucose Tolerance Test in Young Adult Twins.

ABSTRACT:

Context

The associations of body mass index (BMI) and liver fat (LF) with circulating prandial metabolomic markers are incompletely understood.

Objective

We aimed to characterize circulating metabolite excursions during an oral glucose tolerance test (OGTT) and evaluate whether the metabolomic signatures of BMI discordance coassociate with LF content.

Design, setting, and participants

We measured 80 metabolite parameters by nuclear magnetic resonance, together with glucose and insulin, during a 2-hour OGTT in 64 monozygotic (MZ) and 73 dizygotic (DZ) twin pairs (aged 22.8 to 36.2 years). Metabolite excursions during the OGTT were compared within BMI-discordant (intrapair difference, BMI ≥ 3 kg/m2) cotwins separately within MZ and DZ pairs. Insulin-based indices were c

SUBMITTER: Ramo JT 

PROVIDER: S-EPMC6287394 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature