Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies.

ABSTRACT:

Context

Although both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid dysfunction and cognitive function are conflicting.

Objective

This study sought to determine the risk of dementia and cognitive decline associated with subclinical thyroid dysfunction among prospective cohorts.

Data sources

We searched in MEDLINE and EMBASE from inception until November 2014.

Study selection

Two physicians identified prospective cohorts that assessed thyroid function and cognitive outcomes (dementia; Mini-Mental State Examination [MMSE]).

Data extraction

Data were extracted by one reviewer following standardized protocols and verified by a second reviewer. The primary outcome was dementia an

SUBMITTER: Rieben C 

PROVIDER: S-EPMC6287525 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature