Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.

ABSTRACT: Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide, and an association between altered bile acid (BA) metabolism, down-regulation of farnesoid X receptor (FXR), which is a master regulator of BA metabolism, and hepatocarcinogenesis has been documented. While global FXR deficiency in mice results in spontaneous HCC with aging, the contribution of tissue-specific FXR deficiency to hepatocarcinogenesis remains unclear. In this study, the prevalence of hepatic tumors, expression of genes related to tumorigenesis, and serum/liver BA levels were compared among male whole-body Fxr-null, hepatocyte-specific Fxr-null (Fxr ^∆Hep), and enterocyte-specific Fxr-null (Fxr ^∆IE) mice at the age of 3, 14, and 20 months. More

SUBMITTER: Takahashi S 

PROVIDER: S-EPMC6287584 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature