Blood-based protein biomarkers for diagnosis of Alzheimer disease.

ABSTRACT:

Objective

To identify plasma biomarkers for the diagnosis of Alzheimer disease (AD).

Design

Baseline plasma screening of 151 multiplexed analytes combined with targeted biomarker and clinical pathology data.

Setting

General community-based, prospective, longitudinal study of aging.

Participants

A total of 754 healthy individuals serving as controls and 207 participants with AD from the Australian Imaging Biomarker and Lifestyle study (AIBL) cohort with identified biomarkers that were validated in 58 healthy controls and 112 individuals with AD from the Alzheimer Disease Neuroimaging Initiative (ADNI) cohort.

Results

A biomarker panel was identified that included markers significantly increased (cortisol, pancreatic polypeptide, insulinlike growth factor

SUBMITTER: Doecke JD 

PROVIDER: S-EPMC6287606 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature