Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival.

ABSTRACT:

Background

Most men diagnosed with prostate cancer have low-risk cancers. How to predict prostate cancer progression at the time of diagnosis remains challenging.

Objective

To identify single nucleotide polymorphisms (SNPs) associated with death from prostate cancer.

Design, setting, and participants

Blood samples from 11 506 men in Sweden were collected during 1991-1996. Of these, 1053 men were diagnosed with prostate cancer and 245 died from the disease. Stage and grade at diagnosis and outcome information were obtained, and DNA from all cases was genotyped.

Outcome measurements and statistical analysis

A total of 6 126 633 SNPs were tested for association with prostate-cancer-specific survival time using a Cox proportional hazard model, adjusted for age, sta

SUBMITTER: Li W 

PROVIDER: S-EPMC6287611 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature