Development and validation of a prognostic signature for preoperative prediction of overall survival in gastric cancer patients.

ABSTRACT:

Background

As a serious challenge for public health, the prognosis of gastric cancer patients is still poor. The current study aimed to develop and validate a prognostic signature to predict the overall survival of gastric cancer patients.

Patients and methods

The dataset in the present study was obtained from The Cancer Genome Atlas database. The present study finally included 343 gastric cancer patients with information on long non-coding RNA (lncRNA) expression and overall survival.

Results

A prognostic model named Eleven-lncRNA signature was constructed according to the expression values of eleven prognostic lncRNA predictors identified by univariate and multivariate Cox regression model. According to time-dependent receiver operating characteristic curves, the Ha

SUBMITTER: Zhu M 

PROVIDER: S-EPMC6287660 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature