Probiotics drive gut microbiome triggering emotional brain signatures.

ABSTRACT: Experimental manipulation of the gut microbiome was found to modify emotional and cognitive behavior, neurotransmitter expression and brain function in rodents, but corresponding human data remain scarce. The present double-blind, placebo-controlled randomised study aimed at investigating the effects of 4 weeks' probiotic administration on behavior, brain function and gut microbial composition in healthy volunteers. Forty-five healthy participants divided equally into three groups (probiotic, placebo and no intervention) underwent functional MRI (emotional decision-making and emotional recognition memory tasks). In addition, stool samples were collected to investigate the gut microbial composition. Probiotic administration for 4 weeks was associated with changes in brain activation pattern

SUBMITTER: Bagga D 

PROVIDER: S-EPMC6287679 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature