Predictors of disease aggressiveness influence outcome from immunotherapy treatment in renal clear cell carcinoma.

ABSTRACT: Renal clear cell carcinoma (RCC) is the most common type of kidney cancer and has a high propensity for metastasis. While treatment with immune checkpoint inhibitors, such as anti-PD-1, have shown modest improvements in survival for RCC, it is difficult to identify responders from non-responders. Attempts to elucidate the mechanisms associated with differential response to checkpoint inhibitors have been limited by small sample size making it difficult to detect meaningful associations. We utilized existing large datasets from The Cancer Genome Atlas (TCGA) to first find predictors of disease aggressiveness in the tumor microenvironment (TME) and hypothesized that these same predictors may influence response to immunotherapy. We found primary metastatic (M1-stage IV) tumors exhibit high im

SUBMITTER: Kamal Y 

PROVIDER: S-EPMC6287778 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature