Bone marrow endothelial cells sustain a tumor-specific CD8⁺ T cell subset with suppressive function in myeloma patients.

ABSTRACT: Endothelial cells (EC) line the bone marrow microvasculature and are in close contact with CD8⁺ T cells that come and go across the permeable capillaries. Because of these intimate interactions, we investigated the capacity of EC to act as antigen-presenting cells (APC) and modulate CD8⁺ T cell activation and proliferation in bone marrow of patients with multiple myeloma (MM) and monoclonal gammopathy of undetermined significance. We found that EC from MM patients show a phenotype of semi-professional APC given that they express low levels of the co-stimulatory molecules CD40, CD80 and CD86, and of the inducible co-stimulator ligand (ICOSL). In addition, they do not undergo the strong switch from immunoproteasome to standard proteasome subunit expression which is typi

SUBMITTER: Leone P 

PROVIDER: S-EPMC6287798 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature