Genetic diversity of the enteroviruses detected from cerebrospinal fluid (CSF) samples of patients with suspected aseptic meningitis in northern West Bank, Palestine in 2017.

ABSTRACT:

Background

Human enterovirus genus showed a wide range of genetic diversity.

Objectives

To investigate the genetic diversity of the enteroviruses isolated in 2017 in northern West Bank, Palestine.

Study design

249 CSF samples from aseptic meningitis cases were investigated for HEV using two RT-PCR protocols targeting the 5' NCR and the VP1 region of the HEV genome. The phylogenetic characterization of the sequenced VP1 region of Echovirus18 (E18) and Coxsackievirus B5 (CVB5) isolated in Palestine along with 27 E18 and 27 CVB5 sequences available from the Genbank were described.

Results

E18 and CVB5 account for 50% and 35% of the successfully HEV types, respectively. Phylogenetic tree of E18 and CVB5 showed three main clusters, with all Palestinian isolates uniq

SUBMITTER: Dumaidi K 

PROVIDER: S-EPMC6287809 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature