Association of Blood Pressure Trajectories in Early Life with Subclinical Renal Damage in Middle Age.

ABSTRACT:

Background

Although high BP is one of the most important factors affecting renal function, whether longitudinal BP trajectories in early life course are associated with renal function damage in later life is unclear.

Methods

To investigate the correlation between BP trajectories from childhood to adulthood and renal function in middle age, we used group-based trajectory models to identify BP trajectories in 2430 individuals (aged 6-15 years old at baseline) participating in the ongoing Hanzhong Adolescent Hypertension Cohort. We tested the association between these trajectories and subclinical renal damage in middle age, adjusting for several covariates.

Results

We identified four distinct systolic BP trajectories among 2430 subjects: low stable, moderate stable, high

SUBMITTER: Zheng W 

PROVIDER: S-EPMC6287870 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature